Search
Statistics
We have 222 registered usersThe newest registered user is raheelmemon
Our users have posted a total of 1140 messages in 613 subjects
If you are seeing this, you have attempted to link to the UpToDate widget but are experiencing a problem. Please visit UpToDate for more information.
Association of Depression With Increased Risk of Dementia in Patients With Type 2 Diabetes
FORUM FOR PSYCHIATRY RESIDENTS :: Psychiatry :: Psychiatry-Neurology-Psychology discussion :: Psychiatry In Depth
Page 1 of 1
Association of Depression With Increased Risk of Dementia in Patients With Type 2 Diabetes
Admin Sat Jan 28, 2012 2:58 pm
Association of Depression With Increased Risk of Dementia in Patients With Type 2 Diabetes
Arch Gen Psychiatry. Published online December 5, 2011.
Context:
Although depression is a risk factor for dementia in the general population, its association with dementia among patients with diabetes mellitus has not been well studied.
Objective:
To determine whether comorbid depression in patients with type 2 diabetes increases the risk of development of dementia.
Design:
The Diabetes and Aging Study was a cohort investigation that surveyed a racially/ethnically stratified random sample of patients with type 2 diabetes.
Main Outcome Measures:
The Patient Health Questionnaire 8, International Classification of Diseases, Ninth Revision (ICD-9) diagnoses of depression, and/or antidepressant prescriptions in the 12 months prior to baseline were used to identify prevalent cases of depression. Clinically recognized dementia was identified among subjects with no prior ICD-9 Clinical Modification (ICD-9-CM) diagnoses of dementia. To exclude the possibility that depression was a prodrome of dementia, dementia diagnoses were only based on ICD-9-CM diagnoses identified in years 3 to 5 postbaseline. The risk of dementia for patients with depression and diabetes relative to patients with diabetes alone was estimated using Cox proportional hazard regression models that adjusted for sociodemographic, clinical, and health risk factors and health use.
Results:
- During the 3- to 5-year period, 80 of 3766 patients (2.1%) with comorbid depression and diabetes (incidence rate of 5.5 per 1000 person-years) vs 158 of 15 473 patients (1.0%) with diabetes alone (incidence rate of 2.6 per 1000 person-years) had 1 or more ICD-9-CM diagnoses of dementia.
- Patients with comorbid depression had a 100% increased risk of dementia during the 3 to 5 years postbaseline (adjusted hazard ratio, 2.02; 95% confidence interval, 1.73-2.35).
Conclusion:
Depression in patients with diabetes was associated with a substantively increased risk for development of dementia compared with those with diabetes alone.
Arch Gen Psychiatry. Published online December 5, 2011.
Context:
Although depression is a risk factor for dementia in the general population, its association with dementia among patients with diabetes mellitus has not been well studied.
Objective:
To determine whether comorbid depression in patients with type 2 diabetes increases the risk of development of dementia.
Design:
The Diabetes and Aging Study was a cohort investigation that surveyed a racially/ethnically stratified random sample of patients with type 2 diabetes.
Main Outcome Measures:
The Patient Health Questionnaire 8, International Classification of Diseases, Ninth Revision (ICD-9) diagnoses of depression, and/or antidepressant prescriptions in the 12 months prior to baseline were used to identify prevalent cases of depression. Clinically recognized dementia was identified among subjects with no prior ICD-9 Clinical Modification (ICD-9-CM) diagnoses of dementia. To exclude the possibility that depression was a prodrome of dementia, dementia diagnoses were only based on ICD-9-CM diagnoses identified in years 3 to 5 postbaseline. The risk of dementia for patients with depression and diabetes relative to patients with diabetes alone was estimated using Cox proportional hazard regression models that adjusted for sociodemographic, clinical, and health risk factors and health use.
Results:
- During the 3- to 5-year period, 80 of 3766 patients (2.1%) with comorbid depression and diabetes (incidence rate of 5.5 per 1000 person-years) vs 158 of 15 473 patients (1.0%) with diabetes alone (incidence rate of 2.6 per 1000 person-years) had 1 or more ICD-9-CM diagnoses of dementia.
- Patients with comorbid depression had a 100% increased risk of dementia during the 3 to 5 years postbaseline (adjusted hazard ratio, 2.02; 95% confidence interval, 1.73-2.35).
Conclusion:
Depression in patients with diabetes was associated with a substantively increased risk for development of dementia compared with those with diabetes alone.
Admin- Admin
- Posts : 948
Points : 2102
Reputation : 0
Join date : 2011-02-19
Location : Philadelphia -
Similar topics» Differential of Patients With Dementia and/or Parkinsonian Disorders: Accuracy of 5 CSF Biomarkers
» Can Diabetes Meds Treat Depression?
» Key Points: Depression and mania in patients with HIV/AIDS
» Association of Weight Gain and Metabolic Syndrome in Patients Taking Clozapine
» Sertraline or mirtazapine for depression in dementia
» Can Diabetes Meds Treat Depression?
» Key Points: Depression and mania in patients with HIV/AIDS
» Association of Weight Gain and Metabolic Syndrome in Patients Taking Clozapine
» Sertraline or mirtazapine for depression in dementia
FORUM FOR PSYCHIATRY RESIDENTS :: Psychiatry :: Psychiatry-Neurology-Psychology discussion :: Psychiatry In Depth
Page 1 of 1
Permissions in this forum:
You cannot reply to topics in this forum
» L-Methylfolate: Who Will benefit
» Vitamins & Supplements in Clinical Practice.
» Imaging Biomarkers for Outcomes in Mild TBI
» Q.5 Clozapine Neutopenia
» Treating Disorders!
» Cortical Abnormalities in Adults & Adolescents with MDD
» Efficacy of Antipsychotics in Pediatric Acute Mania
» Obsessive Compulsive Disorder in Adults: Which Treatment is Better?