Search
Statistics
We have 222 registered usersThe newest registered user is raheelmemon
Our users have posted a total of 1140 messages in 613 subjects
If you are seeing this, you have attempted to link to the UpToDate widget but are experiencing a problem. Please visit UpToDate for more information.
Sertraline or mirtazapine for depression in dementia
FORUM FOR PSYCHIATRY RESIDENTS :: Psychiatry :: Psychiatry-Neurology-Psychology discussion :: Psycho-Pharmacology
Page 1 of 1
Sertraline or mirtazapine for depression in dementia
Admin Tue Jul 19, 2011 7:43 pm
Sertraline or mirtazapine for depression in dementia (HTA-SADD): a randomised, multicentre, double-blind, placebo-controlled trial
Results:
Decreases in depression scores did not differ between controls & participants allocated to receive sertraline or mirtazapine , or between participants in the mirtazapine and sertraline groups. Also adverse events were noted.
Interpretation:
Because of the absence of benefit compared with placebo and increased risk of adverse events, the present practice of use of these antidepressants, with usual care, for first-line treatment of depression in Alzheimer's disease should be reconsidered.
Note: HTA-SDD= Health Technology Assessment Study of the Use of Antidepressants for Depression in Dementia.
Read the complete article at -->The Lancet, Early Online Publication, 18 July 2011
Results:
Decreases in depression scores did not differ between controls & participants allocated to receive sertraline or mirtazapine , or between participants in the mirtazapine and sertraline groups. Also adverse events were noted.
Interpretation:
Because of the absence of benefit compared with placebo and increased risk of adverse events, the present practice of use of these antidepressants, with usual care, for first-line treatment of depression in Alzheimer's disease should be reconsidered.
Note: HTA-SDD= Health Technology Assessment Study of the Use of Antidepressants for Depression in Dementia.
Read the complete article at -->The Lancet, Early Online Publication, 18 July 2011
Admin- Admin
- Posts : 948
Points : 2102
Reputation : 0
Join date : 2011-02-19
Location : Philadelphia -
Similar topics» Mood Switch in Bipolar Depression: Comparison of Adjunctive Venlafaxine, Bupropion and Sertraline
» Adjunct Mirtazapine for Negative Symptoms of Schizophrenia
» Risk of Switch in Polarity in Bipolar Depression During Acute and Continuation Trials of Venlafaxine, Sertraline, and Bupropion as Adjuncts to Mood Stabilizers
» Early Coadministration of Clonazepam with Sertraline for Panic disorder
» Neuropsychological Deficit: Subcortical Vascular Dementia Vs Alzheimer's Dementia
» Adjunct Mirtazapine for Negative Symptoms of Schizophrenia
» Risk of Switch in Polarity in Bipolar Depression During Acute and Continuation Trials of Venlafaxine, Sertraline, and Bupropion as Adjuncts to Mood Stabilizers
» Early Coadministration of Clonazepam with Sertraline for Panic disorder
» Neuropsychological Deficit: Subcortical Vascular Dementia Vs Alzheimer's Dementia
FORUM FOR PSYCHIATRY RESIDENTS :: Psychiatry :: Psychiatry-Neurology-Psychology discussion :: Psycho-Pharmacology
Page 1 of 1
Permissions in this forum:
You cannot reply to topics in this forum
» L-Methylfolate: Who Will benefit
» Vitamins & Supplements in Clinical Practice.
» Imaging Biomarkers for Outcomes in Mild TBI
» Q.5 Clozapine Neutopenia
» Treating Disorders!
» Cortical Abnormalities in Adults & Adolescents with MDD
» Efficacy of Antipsychotics in Pediatric Acute Mania
» Obsessive Compulsive Disorder in Adults: Which Treatment is Better?