Q: Which Prednisone Dose is Considered Cutoff for Prevention of Steroid Induced Psychosis

Q: Which Prednisone dose is considered cutoff for prevention of steroid induced psychosis (based on most published studies).
(a) 20 mg/day
(b) 40 mg/day
(c) 60 mg/day
(d) 80 mg/day

 

Admin wrote:Q: Which Prednisone dose is considered cutoff for prevention of steroid induced psychosis (based on most published studies).
(a) 20 mg/day
(b) 40 mg/day
(c) 60 mg/day
(d) 80 mg/day

 

A strong dose-response relationship was first demonstrated in 1972 by the Boston Collaborative Drug Surveillance Program in which 718 consecutive hospitalized patients
receiving prednisone therapy were studied.
The incidence of psychiatric symptoms in patients on 40 mg/day was 1.3%, while the incidence in patients receiving 41– 80 mg/day was 4.6%, and the incidence in patients receiving
80 mg/day was 18.4%.

Source: Boston Collaborative Drug Surveillance Program. Acute adverse reactions to prednisone in relation to dosage. Clin Pharmacol Ther Sep–Oct 1972; 13(5):694–698