SNRIs (Venlafaxine & Duloxetine): Associated With in Hospital Morbidity but Not Bleeding or Late Mortality After CABG Surgery

SNRIs (Venlafaxine & Duloxetine): Associated With in Hospital Morbidity but Not Bleeding or Late Mortality After CABG Surgery
Heart Lung Circ. 2012 Jan 27.


- 4136 patients underwent CABG surgery between January 1996 and December 2008 and 105 (2.5%) were SSRI/SNRI users.
- Bleeding events included platelet, fresh frozen plasma and packed red blood cell transfusion, reoperation for bleeding and gastrointestinal bleeding.
- In-hospital morbidity included renal failure, stroke, ventilation >24h, deep sternal wound infection, reoperation (any cause), myocardial infarction and mortality.

RESULTS:
- Median follow-up was 4.7years (interquartile range, 2.3-7.9years) and there were 727 deaths (17.6% of total).
- Use of SSRI/SNRI was associated with new requirement for renal dialysis (adjusted OR=2.18; 95% CI, 1.06-4.45, p=.03) and ventilation >24h (adjusted OR=1.69; 95% CI, 1.03-2.78, p=.04).
- Neither SSRI/SNRI use nor SSRI/SNRI and concomitant anti-platelet medication increased the odds for any bleeding events (all p>.20).
- No association was evident with all-cause mortality (adjusted hazard ratio=1.60; 95% CI .59-4.35, p=.36), or cardiac mortality (adjusted hazard ratio=.31; 95% CI, .04-2.26, p=.25).

CONCLUSIONS:
SSRI/SNRI users experienced an increased risk of renal dysfunction and prolonged ventilation, but not bleeding events or long-term mortality after CABG surgery.

Source: http://www.ncbi.nlm.nih.gov/pubmed/22285303

Also check the difference between Duloxetine and Venlafaxine (Educational):