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Daily Melatonin Administration Attenuates Age-Dependent Disturbances of Cardiovascular Rhythms.

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Daily Melatonin Administration Attenuates Age-Dependent Disturbances of Cardiovascular Rhythms.

Post  Admin on Sat May 21, 2016 3:41 pm

Daily Melatonin Administration Attenuates 
Age-Dependent Disturbances of Cardiovascular Rhythms.

Aim of Study: If cardiovascular changes in elderly (hypertension and reduced robustness of circadian rhythms) can be reversed by daily melatonin ingestion.

Study Population: 
n= 97 normotensive and hypertensive volunteers
Genders: both  
Age: 63-91 yr

Duration of study: 3 weeks.
After 1 week (control)- part of the group (n=63) received 1.5 mg melatonin (MelaxenTM) each day at 22:30 h for 2 weeks. 
The other 34 subjects were placebo-treated. 
Measures: Systolic blood pressure (SBP), diastolic blood pressure (DBP) and heart rate (HR) were measured using semi-automated devices at 03:00, 08:00, 11:00, 14:00, 17:00, 23:00 h each day of the first and the third week. 

* The 24-h HR rhythm was monophasic as described in other studies for young subjects though with a steeper increase in the morning. 
* The daily SBP and DBP rhythms were bimodal. 
* In reference to previously reported data of younger subjects, mean blood pressure of our cohort was elevated, particularly the nocturnal fall was less pronounced. 
* The overall SBP variability was higher as was the percentage of the 12-h component. 
* Both values and also the SBP and DBP levels were reduced during melatonin treatment. 
* The hypotensive effect of melatonin was most pronounced between 3:00 and 8:00 in the morning, i.e. at the time of the highest risk of adverse cardiovascular events, and in subjects with highest BP values before treatment. 
* Moreover, the morning increase of HR was gentler what could have been of additional benefit.

Melatonin has a direct hypotensive effect. Also, it stabilizes the internal temporal order enhancing the circadian component and the synchronization between rhythms of different physiological functions. 

Taken together this data show the usefulness of melatonin for adjuvant medication.


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