Follow Forum_Psych on Twitter

Display results as :

Rechercher Advanced Search

We have 222 registered users
The newest registered user is raheelmemon

Our users have posted a total of 1140 messages in 613 subjects
If you are seeing this, you have attempted to link to the UpToDate widget but are experiencing a problem. Please visit UpToDate for more information.

Is Methylphenidate Safe in Pregnancy?

Go down

Is Methylphenidate Safe in Pregnancy?

Post  Admin on Sat Aug 22, 2015 1:09 pm

Methylphenidate in Pregnancy:
Pharmacokinetics and Pharmacodynamics

* The main factor controlling absorption from immediate release preparations is probably gastric emptying time, whereas for slow release preparations it is the programmed drug release and solution pattern:-
- Prolongation of gastric emptying during pregnancy, could increase the time to peak plasma dose for the immediate release form.

* Methylphenidate is metabolized through esterification by gut enzymes. P450 enzymes have a minimal metabolizing role and therefore increased activity of these enzymes in pregnancy is unlikely to cause any effect on methylphenidate plasma concentration.

* Changes in volume of distribution during pregnancy may affect therapeutic effects of methylphenidate, and adjustment of dose may be necessary depending on clinical response.

* Drugs that are more likely to cross the placenta are:
(a) not protein bound,
(b) have a molecular weight of < 500 Daltons (Da),
(c) have a long half-life,
(d) are lipid soluble and
(e) weak acids.

* Methylphenidate exhibits low plasma protein binding (approximately 15%) and, has a molecular weight of only 269.8 Da, but it has a short half-life (1.4–4.2 h) and is freely soluble in water.
Overall the chemical characteristics of methylphenidate suggest some possibility that it may be able to cross the materno-fetal barrier and reach the fetal circulation.

So Is Methylphenidate Safe in Pregnancy and Lactation ?

Source: Br J Clin Pharmacol. 2014 Jan; 77(1): 96–101.

Click on to post your comments

Posts : 948
Points : 2102
Reputation : 0
Join date : 2011-02-19
Location : Philadelphia

Back to top Go down

Back to top

- Similar topics

Permissions in this forum:
You cannot reply to topics in this forum