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Haloperidol & Fluphenazine Decanoate & Risperidone Consta- Dose Calculation

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Haloperidol & Fluphenazine Decanoate & Risperidone Consta- Dose Calculation

Post  Admin on Mon Jun 10, 2013 8:10 pm

Q: How to calculate Haloperidol/Fluphenazine Decanoate/Risperidone Consta dose from Haloperidol/Fluphenazine/Risperidone Oral dose?

Ans: Rough rule of thumb:
Fluphenazine 10mg/day oral = Fluphenazine Decanoate 12.5mg IM Q 2 weeks.
Haloperidol 10mg/day oral = Haloperidol Decanoate 100mg IM Q 4 weeks.
Risperidone 2-3 mg PO = Risperidone Consta 25 mg Q 2weeks.

Note: Both medication differ in terms of their pharmacokinetics:
* Fluphenazine Decanoate: Effective serum level is established within1- 2 days --> more incidence of side effects few days after each injection.
* Haloperidol Decanoate: Effective serum level is achieved after several weeks --> because of slow uptake --> as a result higher loading dose can be given initially followed few months by taper to baseline dose.

Please add useful basic clinical information regarding long acting antipsychotic injectables here.

Last edited by Admin on Sun Jun 28, 2015 8:29 pm; edited 1 time in total

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