FORUM FOR PSYCHIATRY RESIDENTS
Would you like to react to this message? Create an account in a few clicks or log in to continue.
Follow Forum_Psych on Twitter
Search
 
 

Display results as :
 


Rechercher Advanced Search

Statistics
We have 222 registered users
The newest registered user is raheelmemon

Our users have posted a total of 1140 messages in 613 subjects
If you are seeing this, you have attempted to link to the UpToDate widget but are experiencing a problem. Please visit UpToDate for more information.
Share

Comparison of Four Atypical Antipsychotics (Aripiprazole, Olanzapine, Quetiapine, and Risperidone) in Pt > Age 40

Go down

Comparison of Four Atypical Antipsychotics (Aripiprazole, Olanzapine, Quetiapine, and Risperidone) in Pt > Age 40 Empty Comparison of Four Atypical Antipsychotics (Aripiprazole, Olanzapine, Quetiapine, and Risperidone) in Pt > Age 40

Post  Admin Wed Nov 28, 2012 6:59 pm


Comparison of Longer-Term Safety and Effectiveness of 4 Atypical Antipsychotics (Aripiprazole, Olanzapine, Quetiapine, and Risperidone) in Patients Over Age 40

Source: J Clin Psychiatry, Online ahead of print: November 27, 2012

Comparison of Four Atypical Antipsychotics (Aripiprazole, Olanzapine, Quetiapine, and Risperidone) in Pt > Age 40 Images20

Methods:
Patients were followed for up to 2 years, with assessments at baseline, 6 weeks, 12 weeks, and every 12 weeks thereafter. Medications were administered employing open-label design and flexible dosages, but with blind raters. The study was conducted from October 2005 to October 2010.

Outcome Measures:
- Primary metabolic markers (body mass index, blood pressure, fasting blood glucose, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triglycerides)
- % of patients who stay on the randomly assigned atypical antipsychotic for at least 6 months
- Psychopathology
- % of patients who develop metabolic syndrome
- % of patients who develop serious and nonserious adverse events.

Results:
- Because of a high incidence of serious adverse events, Quetiapine was discontinued midway through the trial.
- There were significant differences among patients willing to be randomized to different atypical antipsychotics (P < .01), suggesting that treating clinicians tended to exclude olanzapine and prefer aripiprazole as one of the possible choices in patients with metabolic problems.
- Yet, the atypical antipsychotic groups did not differ in longitudinal changes in metabolic parameters or on most other outcome measures.
- High discontinuation rate (median duration 26 weeks prior to discontinuation)
- Lack of significant improvement in psychopathology
- High cumulative incidence of metabolic syndrome (36.5% in 1 year) and of serious (23.7%) and nonserious (50.8%) adverse events for all atypical antipsychotics in the study.

Conclusions:
- Lack of effectiveness and a high incidence of side effects with four commonly prescribed atypical antipsychotics across diagnostic groups in patients over age 40, with relatively few differences among the drugs.
- Caution in the use of these drugs is warranted in middle-aged and older patients.
Admin
Admin
Admin
Admin

Posts : 948
Points : 2102
Reputation : 0
Join date : 2011-02-19
Location : Philadelphia

https://psychiatry.forumotion.com

Back to top Go down

Back to top


 
Permissions in this forum:
You cannot reply to topics in this forum