Efficacy of Topical Sialogogue Spray (1% Malic Acid) for Antidepressant Induced Dry Mouth

The aim of this study was to evaluate the clinical efficacy of a topical sialogogue spray containing 1% malic acid on patients affected by dry mouth caused by antidepressants drug.

MATERIALS AND METHODS:
* double-blind, randomized clinical trial at Faculty of Dentistry of University of Granada (Spain). 
* n= 17 participants with antidepressant-induced dry mouth were divided into two groups=
FIRST "intervention group": 35 subjects- topical sialogogue spray (1% malic acid) was applied
SECOND "control group": 35 subjects- placebo spray was applied
* for both groups, the sprays were applied on demand during 2 weeks. 
* Dry Mouth Questionnaire (DMQ) was used to evaluate dry mouth symptoms before and after product/placebo application. 
* Unstimulated and stimulated salivary flows rates, before and after application, were measured.

RESULTS:
* Dry mouth symptoms improved after 1% malic acid topical spray application (p < .05). 
* After 2 weeks of 1% malic acid application, unstimulated and stimulated salivary flows rates increased significantly (p < .05).

CONCLUSIONS:
A sialogogue spray containing 1% malic acid improved dry mouth feeling of the patients suffering antidepressant-induced dry mouth and increased unstimulated and stimulated salivary flows rates.

Source: Depress Anxiety. 2013. Feb;30(2):137-42.