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COMT Inhibitor Entacapone Shows Promise in Alcohol Dependence

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COMT Inhibitor Entacapone Shows Promise in Alcohol Dependence

Post  Admin on Sat Dec 17, 2011 1:47 am

COMT Inhibitor Entacapone Shows Promise in Alcohol Dependence

From American Academy of Addiction Psychiatry (AAAP) 22nd Annual Meeting & Symposium
Source: Medscape Medical News

"This is the first study of its kind to show COMT inhibition as a potential pharmacological method of combatting alcohol craving," principal investigator Rahim Shafa, MD, scientific director at MetroWest CNS Research Center in Natick, Massachusetts, told Medscape Medical News.

"For decades, a need has been recognized for a tolerable, non–habit forming compound to balance out the hypodopaminergic state of drug craving. In our study population, entacapone was effective to counteract both cue craving and ordinary mental craving, which is usually a product of nostalgia from getting high," note the investigators.

They add that entacapone was also effective in alleviating alcoholic post-withdrawal dysphoria.

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